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Suzanne A Eccles Selected Research

PI 540

7/2009Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941.

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Suzanne A Eccles Research Topics

Disease

74Neoplasms (Cancer)
05/2022 - 01/2004
15Neoplasm Metastasis (Metastasis)
10/2019 - 11/2003
12Breast Neoplasms (Breast Cancer)
05/2022 - 01/2006
9Squamous Cell Carcinoma of Head and Neck
01/2018 - 10/2002
8Carcinoma (Carcinomatosis)
10/2018 - 03/2006
7Colorectal Neoplasms (Colorectal Cancer)
01/2018 - 11/2003
6Glioblastoma (Glioblastoma Multiforme)
10/2017 - 07/2009
5Neuroblastoma
11/2020 - 01/2011
4Prostatic Neoplasms (Prostate Cancer)
10/2018 - 11/2007
3Triple Negative Breast Neoplasms
01/2022 - 12/2014
3Ovarian Neoplasms (Ovarian Cancer)
11/2018 - 12/2007
3Hypoxia (Hypoxemia)
08/2017 - 04/2008
3Glioma (Gliomas)
11/2016 - 02/2009
3Squamous Cell Carcinoma (Epidermoid Carcinoma)
07/2013 - 08/2004
3Lung Neoplasms (Lung Cancer)
11/2010 - 08/2004
2Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
01/2020 - 10/2012
2Melanoma (Melanoma, Malignant)
10/2017 - 04/2008
2Brain Neoplasms (Brain Tumor)
09/2017 - 02/2009
2Necrosis
04/2014 - 03/2012
2Head and Neck Neoplasms (Head and Neck Cancer)
12/2011 - 01/2005
1Hypotension (Low Blood Pressure)
01/2020
1Diffuse Intrinsic Pontine Glioma
01/2019
1Hyperoxia
01/2018

Drug/Important Bio-Agent (IBA)

21Biomarkers (Surrogate Marker)IBA
10/2018 - 01/2006
13Proteins (Proteins, Gene)FDA Link
11/2013 - 01/2004
12Pharmaceutical PreparationsIBA
01/2018 - 01/2005
10Phosphotransferases (Kinase)IBA
01/2022 - 01/2004
8ErbB Receptors (EGF Receptor)IBA
05/2015 - 10/2002
7Heat-Shock Proteins (Heat-Shock Protein)IBA
11/2018 - 03/2006
6Phosphatidylinositols (Phosphatidylinositol)IBA
11/2013 - 01/2004
5tanespimycin (17AAG)IBA
11/2018 - 03/2006
4Paclitaxel (Taxol)FDA LinkGeneric
01/2022 - 03/2006
4GemcitabineFDA Link
01/2016 - 01/2010
4Protein Isoforms (Isoforms)IBA
07/2013 - 01/2004
45- (2,4- dihydroxy- 5- isopropylphenyl)- 4- (4- morpholin- 4- ylmethylphenyl)isoxazole- 3- carboxylic acid ethylamideIBA
01/2012 - 01/2008
4LigandsIBA
12/2011 - 10/2002
4Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA
02/2009 - 01/2004
3HMGB1 Protein (HMG1)IBA
05/2022 - 12/2014
3Carboplatin (JM8)FDA LinkGeneric
11/2018 - 12/2007
3bisbenzimide ethoxide trihydrochloride (Hoechst 33342)IBA
01/2018 - 03/2012
3Amino AcidsFDA Link
10/2017 - 08/2008
32- (1H- indazol- 4- yl)- 6- (4- methanesulfonylpiperazin- 1- ylmethyl)- 4- morpholin- 4- ylthieno(3,2- d)pyrimidineIBA
01/2016 - 09/2008
3Molecular Chaperones (Chaperone, Molecular)IBA
11/2013 - 01/2008
3Small Interfering RNA (siRNA)IBA
11/2013 - 12/2007
3Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
07/2012 - 02/2009
3Biological ProductsIBA
03/2012 - 10/2002
3PI103IBA
03/2012 - 02/2009
3Antineoplastic Agents (Antineoplastics)IBA
01/2011 - 01/2010
32- (4- morpholinyl)- 8- phenyl- 4H- 1- benzopyran- 4- oneIBA
06/2007 - 08/2004
2Doxorubicin (Adriamycin)FDA LinkGeneric
01/2022 - 12/2014
2Temozolomide (Temodar)FDA LinkGeneric
11/2020 - 02/2009
2Transcription Factors (Transcription Factor)IBA
11/2020 - 07/2013
2AT13148IBA
01/2020 - 07/2012
2BOS172722IBA
10/2019 - 01/2018
2Choline (Choline Chloride)IBA
10/2018 - 05/2009
2pimonidazoleIBA
01/2018 - 08/2017
2Oxygen (Dioxygen)IBA
01/2018 - 07/2013
2Tyrosine Kinase InhibitorsIBA
01/2018 - 07/2013
2Phosphatidylcholines (Phosphatidylcholine)IBA
10/2017 - 01/2016
2Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
10/2017 - 11/2013
2Evans Blue (Blue, Evans)FDA Link
09/2017 - 07/2015
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
09/2017 - 03/2006
2ferumoxtran-10 (ultrasmall superparamagnetic iron oxide)IBA
11/2016 - 09/2010
2Mediator ComplexIBA
02/2016 - 12/2015
2Peptides (Polypeptides)IBA
07/2015 - 12/2013
2Adenosine Triphosphate (ATP)IBA
12/2013 - 07/2012
2Gefitinib (Iressa)FDA Link
07/2013 - 12/2011
23- ((1- (dimethylamino)propan- 2- yl)oxy)- 5- ((4- methoxy- 5- (1- methyl- 1H- pyrazol- 4- yl)pyridin- 2- yl)amino)pyrazine- 2- carbonitrileIBA
11/2012 - 10/2012
2Aurora KinasesIBA
10/2012 - 11/2011
2Irinotecan (Camptosar)FDA LinkGeneric
10/2012 - 12/2011
2Therapeutic UsesIBA
03/2012 - 04/2008
2Lapatinib (GW572016)FDA Link
12/2011 - 01/2011
2Messenger RNA (mRNA)IBA
09/2009 - 08/2008
2Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
09/2009 - 05/2009
2Cytotoxins (Cytolysins)IBA
02/2009 - 03/2006
2WortmanninIBA
01/2006 - 08/2004
2Matrix Metalloproteinases (MMPs)IBA
08/2004 - 11/2003
1B7-H1 AntigenIBA
05/2022
1Advanced Glycation End ProductsIBA
05/2022
1Adrenergic Agents (Adrenergic Drugs)IBA
11/2020
1CYC065IBA
11/2020
1N,N-dimethylarginine (asymmetric dimethylarginine)IBA
01/2020
1quizartinibIBA
01/2020
1Histones (Histone)IBA
10/2019
1Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
01/2019
1dipinacoline glutamateIBA
01/2019
1MK 2206IBA
10/2018
1Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link
01/2018
1regorafenibIBA
01/2018
1Immunoglobulins (Immunoglobulin)IBA
01/2018
1Phenobarbital (Luminal)FDA Link
10/2017
1Estrogen ReceptorsIBA
10/2017
1SphingomyelinsIBA
10/2017
1Receptor for Advanced Glycation End ProductsIBA
10/2017
1CH 4987655IBA
10/2017
1Progesterone Receptors (Progesterone Receptor)IBA
10/2017
1propionylcarnitineIBA
10/2017

Therapy/Procedure

16Therapeutics
11/2020 - 01/2004
7Drug Therapy (Chemotherapy)
01/2022 - 08/2004
5Oral Administration
10/2016 - 07/2010